Curriculum Vitae
PROFESSIONAL EXPERIENCE
1998-Present Consultant
1980 -1998 Atlantic Richfield, Los Angeles: Manager, Corporate Health & Safety;
Manager, Corporate Toxicology; Manager of Technical Services, Toxicology;
Staff Consultant, Toxicology; Senior Toxicologist
1977 -1980 Diamond Shamrock Corporation, Cleveland: Senior Toxicologist/
Pathologist; Toxicologist
EDUCATION AND CERTIFICATION
1977 Ph.D. Experimental Pathology and Toxicology, Institute of
Comparative and Human Toxicology, Albany Medical
College of Union University, Albany, New York
1971 B.S. Biology, State University of New York at Albany,
Albany, New York
1981 Diplomate, American Board of Toxicology
1986 Recertified as Diplomate, American Board of Toxicology
1991 Recertified as Diplomate, American Board of Toxicology
1996 Recertified as Diplomate, American Board of Toxicology
2001 Recertified as Diplomate, American Board of Toxicology
2006 Recertified as Diplomate, American Board of Toxicology
ACADEMIC APPOINTMENTS AND INVITED PRESENTATIONS
Adjunct Professor of Molecular Pharmacology and Toxicology, Department of Molecular Pharmacology and Toxicology, University of Southern California
Presentations given at the University of Southern California Medical School; United States Military Academy; California State University, Northridge; San Diego State University; University of California at Los Angeles; ARCO executive seminars and numerous professional and trade association meetings. Topics included: EH&S management techniques, economic analysis of health and safety strategies, toxicology, hazard and risk assessment, risk communication, waste site remediation, risk indexing systems, and legal issues in EH&S.(see representative titles)
PROFESSIONAL AND TRADE ASSOCIATIONS (Past and Current)
Co-founder and President, Southern California Regional Chapter, Society of Toxicology
Councilor, Southern California Regional Chapter, Society of Risk Analysis
Society of Toxicology
American College of Toxicology
International Society of Regulatory Toxicology and Pharmacology
Editorial Board, Regulatory Toxicology and Pharmacology
Advisory Board, Association for the Environmental Health of Soils
Program Planning Committee, American College of Toxicology
American Petroleum Institute
PUBLICATIONS, ABSTRACTS AND POSTERS
D. Warrington, J.B. Silkworth, K.F. Benitz, R.N. Roth and L.D. Loose, Cadmium Mediated Cellular Dysfunction, Toxicology and Applied Pharmacology, 41, 1977, p. 206.
K.F. Benitz, R.N. Roth and F. Coulston, Morphologic Characteristics of Hepatic Nodules Induced by Mirex and Dieldrin in Mice, Toxicology and Applied Pharmacology, 41, 1977, p.154.
D.W. Simpson, R.N. Roth and L.D. Loose, A Rapid Inexpensive and Easily Quantified Assay for Phagocytosis and Microbiocidal Activity of Macrophages and Neutrophils, Journal of Immunological Methods, 29, 1979, p.221.
K.F. Benitz and R.N. Roth, A Spontaneous Metastasizing Exocrine Adenocarcinoma of the Pancreas of the Rat, Laboratory Animal Science, 30, 1980, p.64.
G.R. Rosenblum, J. Siva, G. Mancini, W.S. Effron and R.N. Roth, An Integrated Risk Management System, Risk Analysis in the Private Sector: Edited by C. Whipple and V. Covello, Plenum Press, New York, 1985.
W.H. Ford, F.J. Koschier, S.C. Lovre, R.N. Roth, M.W. Carter, and R.E. Seegmiller, A Developmental Toxicity Screen in Rats for Assessing the Effects of Dermal Exposure to Chemicals Found in the Workplace, The Toxicologist, 12(1), 1992, p.102.
A. Hoberman, M. Christian, S. Lovre, R. Roth, and F. Koschier, Developmental Toxicity Study of Carbon Black Oil (CBO) in the Rat, The Toxicologist, 12(1), 1992, p. 105.
F.J. Koschier, R.N. Roth, T.J. Stephens, E.T. Spence, H.K. Kasbarian and M.A. Duke, Evaluation of the Skin Irritation Potential of Petroleum Based Compounds in Reconstituted Human Skin Models, Poster, John Hopkins Center for Alternatives to Animal Testing 10th Annual Meeting, April, 1992.
F.J. Koschier, R.N. Roth, K.A. Wallace, R.D. Curren, and J.W. Harbell, The Use of Three-Dimensional Human Skin Models to Evaluate the Dermal Irritation of Selected Petroleum Products, Poster, World Congress on Alternatives and Animal Use in the Life Sciences, April, 1992.
F.J. Koschier, R.N. Roth, T.J. Stephens, E.T. Spence and M.A. Duke, In Vitro Skin Irritation Testing of Petroleum-Based Compounds in Reconstituted Human Skin Models, Journal Toxicology- Cutaneous & Ocular Toxicology, 13(1), 1994. pp. 23-37
F.J. Koschier, R.N. Roth, and L.A. Schaeffer, Developmental and Reproductive Toxicity of Clarified Slurry Oil (CSO) in the Rat, Fundamental and Applied Toxicology, 28(1), 1995, p.34.
F.J. Koschier, R.N. Roth, K.A. Wallace, R.D. Curren, and J.W. Harbell, A Comparison of Three-Dimensional Human Skin Models to Evaluate the Dermal Irritation of Selected Petroleum Products, In Vitro Toxicology, 10, 1998, p.391-405.
F.J. Koschier, R.N. Roth, K.A. Wallace, R.D. Curren, and J.W. Harbell, A Comparison of Three-Dimensional Human Skin Models to Evaluate the Dermal Irritation of Selected Petroleum Products, Johns Hopkins Center for Alternatives to Animal Testing 1995 Symposium, March, 1995.
A. Hoberman, M. Christian, S. Lovre, R. Roth, and F. Koschier, Reproductive Toxicity of Clarified Slurry Oil (CSO) in the Rat, Journal of the American College of Toxicology, 14, 1995, p.119.
D.B Menzel, R.E. Rasmussen, E. Lee, D.M. Meacher, V. Said, H. Hamadeh, M. Vargas, H. Greene, R.N. Roth, Human Lymphocyte Heme Oxygenase 1 as a Response Biomarker to Inorganic Arsenic, Biochem. Biophys. Res. Comm., 250(3), 1998, p. 653.
D.B Menzel, H. Hamadeh, E. Lee, D.M. Meacher, V. Said, R.E. Rasmussen, H. Greene, R.N. Roth, Arsenic Binding Proteins from Human Lymphoblastoid Cells, Toxicol. Lett., 105(2), 1999, p. 89.
C. Lapin, Q. Bui, R. Breglia, F. Koschier, P. Podhasky, E. Lapadula, R. Roth, C. Schreiner, R. White, C. Clark, R. Mandella, and G. Hoffman, Toxicity Evaluation of Petroleum Blending Streams: Inhalation Subchronic Toxicity/Neurotoxicity Study of a Light Catalytic Cracked Naphtha Distillate in Rats, International J. of Toxicology, 20, 2001, p.: 307-319.
B. Simpson, W. Dalbey, J. Fetzer, J. Murray, M. Nicolich, R. Roth, M. Saperstein, R. White and T. Gray, The Relationship between the Aromatic Ring Class Content and Repeat-dose and Developmental Toxicities of Petroleum Substances Boiling above Approximately 300 ºF, The Toxicologist, Supplement to Toxicological Sciences Volume 102(1), March, 2008, p. 52.
A. Kuhl, D. Stump, K. Goyak, R. Biles and R. Roth, Lack of Developmental Toxicity in Rats After Dermal Administration of a Solvent-Dewaxed Heavy Paraffinic Petroleum Distillate, The Toxicologist, March, 2010.
Invited Presentations (Representative titles)
"The Role of Toxicology in Risk Management"
"The Utility of Short-Term Tests in Risk Assessment"
"Scientific Uncertainty Associated with Health Risk Assessment"
"Toxicity of Hazardous Wastes"
"The Relationship of Toxicology and Industrial Hygiene in the Risk Assessment Process"
"Assessment and Regulation of Genotoxic Chemicals"
"Assessing the Return on Health and Safety Investments"
"Legal Issues in Toxicology"
"Quality Assurance and Its Role in Industrial Toxicology"
"A Relative Risk Indexing System for Industrial Operations"
"Methanol's Health Risks"
"The State of Risk Communication Today"
"Environmental Toxicology"
"To MTBE or Not MTBE: That is the Question"
"EH&S Five Year Trends: Strategic Significance"
PROFESSIONAL EXPERIENCE
1998-Present Consultant
1980 -1998 Atlantic Richfield, Los Angeles: Manager, Corporate Health & Safety;
Manager, Corporate Toxicology; Manager of Technical Services, Toxicology;
Staff Consultant, Toxicology; Senior Toxicologist
1977 -1980 Diamond Shamrock Corporation, Cleveland: Senior Toxicologist/
Pathologist; Toxicologist
EDUCATION AND CERTIFICATION
1977 Ph.D. Experimental Pathology and Toxicology, Institute of
Comparative and Human Toxicology, Albany Medical
College of Union University, Albany, New York
1971 B.S. Biology, State University of New York at Albany,
Albany, New York
1981 Diplomate, American Board of Toxicology
1986 Recertified as Diplomate, American Board of Toxicology
1991 Recertified as Diplomate, American Board of Toxicology
1996 Recertified as Diplomate, American Board of Toxicology
2001 Recertified as Diplomate, American Board of Toxicology
2006 Recertified as Diplomate, American Board of Toxicology
ACADEMIC APPOINTMENTS AND INVITED PRESENTATIONS
Adjunct Professor of Molecular Pharmacology and Toxicology, Department of Molecular Pharmacology and Toxicology, University of Southern California
Presentations given at the University of Southern California Medical School; United States Military Academy; California State University, Northridge; San Diego State University; University of California at Los Angeles; ARCO executive seminars and numerous professional and trade association meetings. Topics included: EH&S management techniques, economic analysis of health and safety strategies, toxicology, hazard and risk assessment, risk communication, waste site remediation, risk indexing systems, and legal issues in EH&S.(see representative titles)
PROFESSIONAL AND TRADE ASSOCIATIONS (Past and Current)
Co-founder and President, Southern California Regional Chapter, Society of Toxicology
Councilor, Southern California Regional Chapter, Society of Risk Analysis
Society of Toxicology
American College of Toxicology
International Society of Regulatory Toxicology and Pharmacology
Editorial Board, Regulatory Toxicology and Pharmacology
Advisory Board, Association for the Environmental Health of Soils
Program Planning Committee, American College of Toxicology
American Petroleum Institute
PUBLICATIONS, ABSTRACTS AND POSTERS
D. Warrington, J.B. Silkworth, K.F. Benitz, R.N. Roth and L.D. Loose, Cadmium Mediated Cellular Dysfunction, Toxicology and Applied Pharmacology, 41, 1977, p. 206.
K.F. Benitz, R.N. Roth and F. Coulston, Morphologic Characteristics of Hepatic Nodules Induced by Mirex and Dieldrin in Mice, Toxicology and Applied Pharmacology, 41, 1977, p.154.
D.W. Simpson, R.N. Roth and L.D. Loose, A Rapid Inexpensive and Easily Quantified Assay for Phagocytosis and Microbiocidal Activity of Macrophages and Neutrophils, Journal of Immunological Methods, 29, 1979, p.221.
K.F. Benitz and R.N. Roth, A Spontaneous Metastasizing Exocrine Adenocarcinoma of the Pancreas of the Rat, Laboratory Animal Science, 30, 1980, p.64.
G.R. Rosenblum, J. Siva, G. Mancini, W.S. Effron and R.N. Roth, An Integrated Risk Management System, Risk Analysis in the Private Sector: Edited by C. Whipple and V. Covello, Plenum Press, New York, 1985.
W.H. Ford, F.J. Koschier, S.C. Lovre, R.N. Roth, M.W. Carter, and R.E. Seegmiller, A Developmental Toxicity Screen in Rats for Assessing the Effects of Dermal Exposure to Chemicals Found in the Workplace, The Toxicologist, 12(1), 1992, p.102.
A. Hoberman, M. Christian, S. Lovre, R. Roth, and F. Koschier, Developmental Toxicity Study of Carbon Black Oil (CBO) in the Rat, The Toxicologist, 12(1), 1992, p. 105.
F.J. Koschier, R.N. Roth, T.J. Stephens, E.T. Spence, H.K. Kasbarian and M.A. Duke, Evaluation of the Skin Irritation Potential of Petroleum Based Compounds in Reconstituted Human Skin Models, Poster, John Hopkins Center for Alternatives to Animal Testing 10th Annual Meeting, April, 1992.
F.J. Koschier, R.N. Roth, K.A. Wallace, R.D. Curren, and J.W. Harbell, The Use of Three-Dimensional Human Skin Models to Evaluate the Dermal Irritation of Selected Petroleum Products, Poster, World Congress on Alternatives and Animal Use in the Life Sciences, April, 1992.
F.J. Koschier, R.N. Roth, T.J. Stephens, E.T. Spence and M.A. Duke, In Vitro Skin Irritation Testing of Petroleum-Based Compounds in Reconstituted Human Skin Models, Journal Toxicology- Cutaneous & Ocular Toxicology, 13(1), 1994. pp. 23-37
F.J. Koschier, R.N. Roth, and L.A. Schaeffer, Developmental and Reproductive Toxicity of Clarified Slurry Oil (CSO) in the Rat, Fundamental and Applied Toxicology, 28(1), 1995, p.34.
F.J. Koschier, R.N. Roth, K.A. Wallace, R.D. Curren, and J.W. Harbell, A Comparison of Three-Dimensional Human Skin Models to Evaluate the Dermal Irritation of Selected Petroleum Products, In Vitro Toxicology, 10, 1998, p.391-405.
F.J. Koschier, R.N. Roth, K.A. Wallace, R.D. Curren, and J.W. Harbell, A Comparison of Three-Dimensional Human Skin Models to Evaluate the Dermal Irritation of Selected Petroleum Products, Johns Hopkins Center for Alternatives to Animal Testing 1995 Symposium, March, 1995.
A. Hoberman, M. Christian, S. Lovre, R. Roth, and F. Koschier, Reproductive Toxicity of Clarified Slurry Oil (CSO) in the Rat, Journal of the American College of Toxicology, 14, 1995, p.119.
D.B Menzel, R.E. Rasmussen, E. Lee, D.M. Meacher, V. Said, H. Hamadeh, M. Vargas, H. Greene, R.N. Roth, Human Lymphocyte Heme Oxygenase 1 as a Response Biomarker to Inorganic Arsenic, Biochem. Biophys. Res. Comm., 250(3), 1998, p. 653.
D.B Menzel, H. Hamadeh, E. Lee, D.M. Meacher, V. Said, R.E. Rasmussen, H. Greene, R.N. Roth, Arsenic Binding Proteins from Human Lymphoblastoid Cells, Toxicol. Lett., 105(2), 1999, p. 89.
C. Lapin, Q. Bui, R. Breglia, F. Koschier, P. Podhasky, E. Lapadula, R. Roth, C. Schreiner, R. White, C. Clark, R. Mandella, and G. Hoffman, Toxicity Evaluation of Petroleum Blending Streams: Inhalation Subchronic Toxicity/Neurotoxicity Study of a Light Catalytic Cracked Naphtha Distillate in Rats, International J. of Toxicology, 20, 2001, p.: 307-319.
B. Simpson, W. Dalbey, J. Fetzer, J. Murray, M. Nicolich, R. Roth, M. Saperstein, R. White and T. Gray, The Relationship between the Aromatic Ring Class Content and Repeat-dose and Developmental Toxicities of Petroleum Substances Boiling above Approximately 300 ºF, The Toxicologist, Supplement to Toxicological Sciences Volume 102(1), March, 2008, p. 52.
A. Kuhl, D. Stump, K. Goyak, R. Biles and R. Roth, Lack of Developmental Toxicity in Rats After Dermal Administration of a Solvent-Dewaxed Heavy Paraffinic Petroleum Distillate, The Toxicologist, March, 2010.
Invited Presentations (Representative titles)
"The Role of Toxicology in Risk Management"
"The Utility of Short-Term Tests in Risk Assessment"
"Scientific Uncertainty Associated with Health Risk Assessment"
"Toxicity of Hazardous Wastes"
"The Relationship of Toxicology and Industrial Hygiene in the Risk Assessment Process"
"Assessment and Regulation of Genotoxic Chemicals"
"Assessing the Return on Health and Safety Investments"
"Legal Issues in Toxicology"
"Quality Assurance and Its Role in Industrial Toxicology"
"A Relative Risk Indexing System for Industrial Operations"
"Methanol's Health Risks"
"The State of Risk Communication Today"
"Environmental Toxicology"
"To MTBE or Not MTBE: That is the Question"
"EH&S Five Year Trends: Strategic Significance"